Prior to the study in question, only small cohorts had been evaluated for CPG island methylation status
correlated with estimating one’s cardiac risk.
This study utilized blood DNA samples from multiple cohort studies in
both the United States and Europe to evaluate epigenome-wide modification of leukocytes
in cardiovascular disease. Areas that were associated with coronary heart
disease were in found genes that play a part in calcium regulation, coronary
artery calcified plaque, and kidney function. Additionally, Mendelian randomization
analysis showed a causal effect of DNA methylation in regulatory regions, both
in non-coding RNA and genes that play a role in normal cellular structure and
function. These findings highlight the clinical utility of methylation states,
as well as identifying less-emphasized pathways in calcium regulation and
kidney function that may significantly contribute to coronary heart disease. This
could lead to new therapeutic targets, new prevention strategies, and novel
diagnostic tools.
Agha,
G., Mendelson, M. M., Ward-Caviness, C. K., Joehanes, R., Huan, T., Gondalia,
R., Salfati, E., Brody, J. A., Fiorito, G., Bressler, J., Chen, B. H.,
Ligthart, S., Guarrera, S., Colicino, E., Just, A. C., Wahl, S., Gieger, C.,
Vandiver, A. R., Tanaka, T., Hernandez, D. G., … Baccarelli, A. A. (2019).
Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction
and Coronary Heart Disease. Circulation, 140(8), 645–657. https://doi.org/10.1161/CIRCULATIONAHA.118.039357
Moore, L. D., Le,
T., & Fan, G. (2013). DNA methylation and its basic function. Neuropsychopharmacology
: official publication of the American College of Neuropsychopharmacology, 38(1),
23–38. https://doi.org/10.1038/npp.2012.112
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