It is fascinating how researchers have begun using Patient Derived Xenograft models for researching tumor microenvironments. One of the biggest issues I found working with PDX models was that they could really only be cultured for 1-2 cycles before needing to be implanted into another organism as with subcutaneous implantation of a tumor PDX model in mice. Utilizing the 3D matrix to overcome some of the scaffolding issues is ingenious, but I would love to know how they account for possible metabolic and genomic changes due to other factors such as outside cytokine signaling. Definitely an awesome avenue for expanding the field of personalized medicine. Thank you!
It is fascinating how researchers have begun using Patient Derived Xenograft models for researching tumor microenvironments. One of the biggest issues I found working with PDX models was that they could really only be cultured for 1-2 cycles before needing to be implanted into another organism as with subcutaneous implantation of a tumor PDX model in mice. Utilizing the 3D matrix to overcome some of the scaffolding issues is ingenious, but I would love to know how they account for possible metabolic and genomic changes due to other factors such as outside cytokine signaling. Definitely an awesome avenue for expanding the field of personalized medicine. Thank you!
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